Combinations ; See Below
1. Rifampicin / Ethambutol / Pyrazinamide / Isoniazid
2. Rifampicin / Isoniazid
3. Rifampicin/Isoniazid/Pyrazinamide
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| R-cin | Lupin Laboratories | Wessex Pharmaceuticals Limited | 150mg | 100 | Capsule | per capsule | KES 340.00 |
| R-cin | Lupin Laboratories | Wessex Pharmaceuticals Limited | 300mg | 100 | Capsule | per capsule | KES 975.00 |
| Rifacos | Cosmos Limited. | Cosmos Limited | 300mg | 100 | Capsule | per capsule | KES 1,700.00 |
| Rifampicin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 150mg | 100 | Capsule | per capsule | KES 450.00 |
| Rifampicin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 300mg | 100 | Capsule | per capsule | KES 700.00 |
| Rifampicin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 150mg | 100 | Capsule | per capsule | KES 460.00 |
| Rifampicin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 300mg | 100 | Capsule | per capsule | KES 460.00 |
| Unirif | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 150mg | 100 | Capsule | per capsule | KES 377.00 |
| Unirif | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 300mg | 100 | Capsule | per capsule | KES 683.00 |
| Akurit | Lupin Laboratories | Wessex Pharmaceuticals Limited | 150mg/75mg | 90 | Tablet | per tablet | KES 500.00 |
| Rifampicin More info | |
|---|---|
| Mode Of Action | Inhibition of DNA-dependent RNA polymerase activity in susceptible bacterial cells. |
| Drug Indication | TB, Leprosy, Brucellosis, Gonorrhoea |
| Precautions | To be administered always with another tuberculostatic agent, pregnancy, impaired liver functions, undernourished patients, late pregnancy (can cause post-natal haemorrhage), immunologic reactions with intermittent therapy, discontinue immediately if signs of hepatocells are noted. |
| Contra-Indications | Jaundice, impaired liver functions, lactation and pregnancy, new born infants. |
| Side Effects | GI disturbances, skin reactions, liver dysfunctions, urine, sputum and tears discoloration, blood dyscrasia, oedema, flu syndrome, shortening of breath, menstruation disorders, acute renal failure, gout, gynaecomastia, aggreviate peptic ulcers, lupus like reactions, blurred vision. Safest antituberculous regimen for use in pregnancy is considered to be rifampin, isoniazid and ethambutol). |
| Dosage | TB and Leprosy: 450-600mg daily in a single dose before breakfast. Brucellosis: 900mg daily at noon in combination with doxycycline 200mg at night for 45 days. Gonorrhoea: 900mg OD for 1-3days. Other infections: 600-1200mg daily in divided doses. Children: Over one month upto 20mg/kg. |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |
Combinations ;
| 1. Rifampicin / Ethambutol / Pyrazinamide / Isoniazid | |
|---|---|
| Mode Of Action | Inhibition of DNA-dependent RNA polymerase activity in susceptible bacterial cells. |
| Drug Indication | Pulmonary TB |
| Precautions | See under rifampicin, etambutol, Isoniazid and pyrazinamide |
| Contra-Indications | See under rifampicin, etambutol, Isoniazid and pyrazinamide |
| Side Effects | See under rifampicin, etambutol, Isoniazid and pyrazinamide |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| AKT-4 | Lupin Laboratories | Wessex Pharmaceuticals Limited | 450mg/800mg/750mg/300mg | 30 | Tablet | per tablet | KES 1,240 |
| Akurit-4 | Lupin Laboratories | Wessex Pharmaceuticals Limited | 150mg/275mg/400mg75mg | 90 | Tablet | per tablet | KES 1,324 |
| Rifafour | Sanofi Aventis | Surgipharm Ltd | 150mg/275mg/400mg75mg | 100 | Tablet | per tablet | KES 5,192.00 |
| Rihaz E | Cosmos Limited. | Cosmos Limited | 150mg/275mg/400mg75mg | 100 | Tablet | per tablet | KES 1,800.00 |
| 2. Rifampicin / Isoniazid | |
|---|---|
| Mode Of Action | Inhibition of DNA-dependent RNA polymerase activity in susceptible bacterial cells. |
| Drug Indication | Pulmonary TB |
| Precautions | See under rifampicin and Isoniazid |
| Contra-Indications | See under rifampicin and Isoniazid |
| Side Effects | See under rifampicin and Isoniazid |
| Dosage | Over 50kg/body weight; 600mg/ 300mg OD. Under 50kg body weight; 450/300mg - 600mg/300mg OD |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Rifinah | Sanofi Aventis | Surgipharm Ltd | 300mg | 40 | Tablet | per tablet | KES 2,126.00 |
| Akurit Z kid | Lupin Laboratories | Wessex Pharmaceuticals Limited | 60mg/30mg/150mg | 90 | Tablet | per tablet | KES 500.00 |
| Rihide | Cosmos Limited. | Cosmos Limited | 150mg/75mg | 100 | Tablet | per tablet | KES 900.00 |
| Rifisal | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 300mg/150mg | 100 | Tablet | per tablet | KES 890.00 |
| R-Cinex | Lupin Laboratories | Wessex Pharmaceuticals Limited | 400mg/300mg | 100 | Tablet | per tablet | KES 1,510.00 |
| 3. Rifampicin / Isoniazid / Pyrazinamide | |
|---|---|
| Mode Of Action | Inhibition of DNA-dependent RNA polymerase activity in susceptible bacterial cells. |
| Drug Indication | Pulmonary TB |
| Precautions | See under rifampicin, Isoniazid and pyrazinamide |
| Contra-Indications | See under rifampicin, Isoniazid and pyrazinamide |
| Side Effects | See under rifampicin, Isoniazid and pyrazinamide |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Ltd. | Ltd | mg | 30 | Tablet | per tablet | KES | |